Journal
BRAIN PATHOLOGY
Volume 18, Issue 1, Pages 113-121Publisher
WILEY
DOI: 10.1111/j.1750-3639.2007.00121.x
Keywords
microRNA; miRNA; Argonaute; Ago; Dicer; RNA; intereference; RNAi; miRNP; RISC; siRNA; mRNA transcription
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Funding
- NICHD NIH HHS [P30-HD026979, P30 HD026979] Funding Source: Medline
- NIGMS NIH HHS [GM0720777] Funding Source: Medline
- NINDS NIH HHS [F30NS054396, NS053839, R21 NS053839, F30 NS054396] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD026979] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [F30NS054396] Funding Source: NIH RePORTER
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Small regulatory RNAs are essential and ubiquitous riboregulators that are the key mediators of RNA interference (RNAi). They include microRNAs (miRNAs) and short-interfering RNAs (siRNAs), classes of similar to 22 nucleotide RNAs. miRNAs and siRNAs bind to Argonaute proteins and form effector complexes that regulate gene expression; in animals, this regulation occurs primarily at the post-transcriptional level. In this review, we will discuss our current understanding of how miRNA and siRNAs are generated and how they function to silence gene expression, focusing on animal and, in particular, mammalian miRNAs.
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