Journal
BRAIN PATHOLOGY
Volume 18, Issue 1, Pages 110-112Publisher
WILEY
DOI: 10.1111/j.1750-3639.2007.00118.x
Keywords
microRNA siRNA; Dicer; RNA-induced Silencing Complex; microRNP; microRNP; Argonaute; dsRNA; RNA interference
Categories
Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD026979] Funding Source: NIH RePORTER
- NICHD NIH HHS [P30 HD026979, P30-HD026979] Funding Source: Medline
- NIGMS NIH HHS [GM0720777] Funding Source: Medline
- NINDS NIH HHS [NS053839, R21 NS053839] Funding Source: Medline
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Biological revolutions are, sometimes, born out of experimental artifacts or from completely unexpected experimental results. Such is the case for the RNA interference (RNAi) and microRNA (miRNA) revolution. I will provide a brief historical account of the birth of this fascinating field; I offer my sincere apologies for any unintended omissions. The reviews that follow present in more detail our current understanding of the field and how it impacts neurobiology and neuropathology, especially brain tumors and neurodegenerative diseases.
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