Determination of Bisphenol A in Plastic Bottled Drinking Water by High Performance Liquid Chromatography with Solid-membrane Extraction Based on Electrospun Nylon 6 Nanofibrous Membrane

Electrospun nylon 6 nanofibrous membrane based on solid membrane extraction-high performance liquid chromatography (SME-HPLC) for the determination of bisphenol A (BPA) in plastic bottled drinking water was performed. Important parameters that effect extraction efficiency such as eluting agent and its volume, flow rate of sample, sample volume, pH value of sample, quality of the membrane, the form of activation and the repeatedly employing of this membrane were optimized. Results indicated that 10 mL of water sample volume with pH value of 8.0 passed through nylon 6 nanofibrous membrane (1.5 mg) at flow rate of 3.0 mL/min; and only 300 mu L eluent ( methanol) was used. Each piece of this membrane would be used at least 6 times. Under the optimized conditions, an excellent linear relationship in the range of 0.2 - 20 mu g/L with correlation coefficients of determination(r) 0.9998 was obtained, the limits of detection (LOD) about BPA was 0.15 mu g/L. The repeatabilities (RSD) intra-membrane and inter-membrane with nylon 6 nanofibrours membrane were all below 4.5% (n=6). The proposed method has been applied to the analysis of plastic bottled purified water of six different brands. Satisfactory spiked recoveries of 94.95% were obtained. BPA was lower than 0.30 mu g/L. A comparison among the SME using nylon 6 nanofibrous membrane and other kinds of SPE sorbents used in literatures was carried out. All the results indicated that the nylon 6 nanofiboous membrane has great potential as a novel material for the enrichment and determination of BPA in water sample.