Journal
BRAIN IMAGING AND BEHAVIOR
Volume 8, Issue 3, Pages 403-406Publisher
SPRINGER
DOI: 10.1007/s11682-014-9309-9
Keywords
fMRI; Memory rehabilitation; Clinical trial
Categories
Funding
- National Institute of Health (NCMRR) [R01 HD045798S, R01 HD045798]
- Kessler Foundation
- NIDRR [H133P090009]
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Cognitive impairment in individuals with multiple sclerosis (MS) is now well recognized. One of the most common cognitive deficits is found in memory functioning, largely due to impaired acquisition. We examined functional brain activity 6 months after memory retraining in individuals with MS. The current report presents long term follow-up results from a randomized clinical trial on a memory rehabilitation protocol known as the modified Story Memory Technique. Behavioral memory performance and brain activity of all participants were evaluated at baseline, immediately after treatment, and 6 months after treatment. Results revealed that previously observed increases in patterns of cerebral activation during learning immediately after memory training were maintained 6 months post training.
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