Journal
BRAIN IMAGING AND BEHAVIOR
Volume 7, Issue 3, Pages 282-292Publisher
SPRINGER
DOI: 10.1007/s11682-013-9226-3
Keywords
Alzheimer's disease; Financial capacity; Magnetic resonance imaging; Frontal cortex; Precuneus; Angular gyrus
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Funding
- National Institute on Aging (Alzheimer's Disease Research Center) [1P50 AG16582-10, 1R01 AG021927-05, 5R01 AG021927]
- Alzheimer's of Central Alabama, the National Institute of Drug Abuse [K23 DA032612]
- Brain & Behavior Research Foundation Young Investigator Award
- Charles A. King Trust
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Persons with mild Alzheimer's disease (AD) have significant deficits in financial abilities. This study examined the relationship between brain structure volumes, cognition, and financial capacity in patients with mild AD. Sixteen mild AD patients and 16 older adult comparisons completed the Financial Capacity Instrument (FCI), a psychometric measure of financial abilities, and also underwent magnetic resonance imaging (MRI) to obtain volumes of the bilateral hippocampi, angular gyri, precunei, and medial and dorsolateral frontal cortices. Mild AD patients performed significantly below comparisons on the FCI and had significantly smaller hippocampi. Among mild AD patients, FCI performance was moderately correlated with frontal (medial and dorsolateral frontal cortex) and posterior (angular gyri and precunei) cortical volumes. Stepwise regression demonstrated that medial frontal cortex volume predicted FCI score. The relationship between medial frontal cortex volume and overall FCI score was partially mediated by two measures of simple attention (DRS Attention, DRS Construction). The findings suggest that medial frontal cortex atrophy and associated declines in simple attention play an increasingly important role in declining financial skills in patients with mild AD.
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