Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 37, Issue -, Pages 1-14Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2013.12.010
Keywords
Microglia; Microglia morphology; Amoeboid microglia; Neuron; Glia; Chronic stress; Glutamate
Categories
Funding
- National Health and Medical Research Council of Australia
- Hunter Medical Research Institute
- University of Newcastle's Brawn Fellowship
- Hunter Medical Research Institute (HMRI)
- Stan.A.Olsson Foundation For Science and Culture
Ask authors/readers for more resources
Microglia are unique cells within the central nervous system because of their biophysical independence. As a result of this unusual property the cells must undergo significant structural remodelling in order to engage and connect with other elements within the central nervous system. Efficient remodelling is required for all activities that microglia are involved in ranging from monitoring synaptic information flow through to phagocytosis of tissue debris. Despite the fact that morphological remodelling is a prerequisite to all microglial activities, relatively little research has been undertaken on the topic. This review examines what is known about how microglia transform themselves during development, under physiological conditions in response to changes in neuronal activity, and under pathological circumstances. Specific attention is given to exploring a variety of models that have been proposed to account for microglial transformation as well as the signals that are known to trigger these transformations. (C) 2014 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available