Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 35, Issue -, Pages 1-8Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2013.09.015
Keywords
Lipopolysaccharide (LPS); Human endotoxemia; Sickness behavior; Cytokines; Experimental inflammation; Immune-to-brain communication; fMRI
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Systemic inflammation is among the most prominent and most frequently observed responses of the immune system. Over the past decades, it has become clear that inflammatory cytokines not only affect immune and metabolic functions but also cause a wide range of behavioral and mood changes. Based on experimental findings in animals and observations in clinical populations it has been hypothesized that inflammation-induced neurocognitive changes contribute to the pathophysiology of neuropsychiatric diseases. However, since certain aspects of human behavior cannot be modeled in laboratory animals, there is a need for human models of systemic inflammation. In this review, we summarize recent studies employing administration of endotoxin as a model to induce transient systemic inflammation in healthy human subjects. (C) 2013 Elsevier Inc. All rights reserved.
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