Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 35, Issue -, Pages 58-63Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2013.08.013
Keywords
Learning behavior; Morris water maze; CD4 T cells; Antigen specificity; OTII mice; 2D2 mice; Pro-cognitive T cells; Meningeal immunity
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Funding
- National Institute on Aging, NIH [AG034113]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007496] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG034113] Funding Source: NIH RePORTER
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Numerous methods of T cell depletion lead to impairment of learning and memory function in mice. While adoptive transfer of whole splenocytes rescues learning behavior impairments, the precise sub-population and antigenic specificity of the T cells mediating the rescue remains unknown. Using several transgenic mouse models in combination with adoptive transfers, we demonstrate the necessity of an antigen-specific CD4(+) T cell compartment in normal spatial learning and memory, as measured by the Morris water maze (MWM). Moreover, transfer of a monoclonal T cell population reactive to the central nervous system (CNS) antigen, myelin oligodendrocyte glycoprotein (MOG), was sufficient to improve cognitive task performance in otherwise impaired OTII mice, raising the possibility that the antigen-specificity requirement of pro-cognitive T cells may be directed against CNS-derived self-antigens. (C) 2013 Elsevier Inc. All rights reserved.
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