Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 28, Issue -, Pages 170-181Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2012.11.010
Keywords
Kynurenine; IDO; Cytokine; Poly I:C; Inflammation; IL-6; IL-1; TNF-alpha; Depression; BDNF; Serotonin
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Funding
- EUFP7 MOODINFLAME consortium
- Trinity College Dublin
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In this study we characterised the ability of the viral mimetic poly I:C to induce a neuroinflammatory response and induce symptoms of depression and anxiety in rats. Furthermore, the ability of poly I:C to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (IDO), and also the ability of poly I:C to impact upon expression of the neurotrophin BDNF and its receptor TrkB were examined as potential mechanisms to link inflammation to depression. Poly I:C induced a neuroinflammatory response characterised by increased expression of IL-1 beta, IL-6, TNF-alpha and CD11b in frontal cortex and hippocampus. In the first 24 h following poly I:C administration rats displayed sickness behaviour characterised by reduced locomotor activity and weight gain. Anhedonia measured using the saccharin preference test was used as an indicator of depressive behaviour, and poly I:C induced depressive behaviour that persisted for up to 72 h following administration. Anxiety was measured using the open field test and anxious behaviour was observed 24 h following poly I:C, a time-point when sickness behaviour had resolved. These behavioural changes were accompanied by decreased expression of BDNF and TrkB in hippocampus and frontal cortex. In addition, poly I:C increased central IDO expression and increased concentrations of tryptophan, and its metabolite kynurenine. However this activation of the kynurenine pathway did not result in reduced central serotonin concentrations. These findings suggest that depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin. (C) 2012 Elsevier Inc. All rights reserved.
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