Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 33, Issue -, Pages 29-32Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2013.05.001
Keywords
Sedentary; Depression; Ageing; Epidemiology; Inflammation; C-reactive protein
Categories
Funding
- National Institute on Aging in the United States [2RO1AG7644-01A1, 2RO1AG017644]
- consortium of UK government departments
- British Heart Foundation [RE/10/005/28,296]
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There is emerging evidence for a link between sedentary behavior and mental health, although the mechanisms remain unknown. We tested if an underlying inflammatory process explains the association between sedentary behavior and depressive symptoms. We conducted a two year follow-up of 4964 (aged 64.5 +/- 8.9 years) men and women from the English Longitudinal Study of Ageing, a cohort of community dwelling older adults. Self-reported TV viewing time was assessed at baseline as a marker of leisure time sedentary behavior. The eight-item Centre of Epidemiological Studies Depression (CES-D) scale was administered to measure depressive symptoms at follow-up. At baseline, TV time was associated with C-reactive protein (CRP), adjusted geometric mean CRP values were 2.94 mg/L (<2 h/d TV); 3.04 mg/L (2-4 h/d TV); 3.29 mg/L (4-6 h/d TV); 3.23 mg/L (>6 h/d TV). We observed both a direct association of TV time on CES-D score at follow-up (B = 0.08, 95% CI, 0.05, 0.10) and indirect effects (B = 0.07, 95% CI, 0.05, 0.08). The indirect effects were largely explained through lack of physical activity, smoking, and alcohol, but not by CRP or body mass index. (c) 2013 Elsevier Inc. All rights reserved.
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