Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 26, Issue 8, Pages 1322-1330Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2012.08.013
Keywords
Parkinson's disease; Dopaminergic neurons; Microglia; CD4 T cells; Regulatory T cells; Neuroinflammation
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Funding
- Korea Science and Engineering Foundation (KOSEF)
- Korea government (MOST) [2009-0063466]
- National Research Foundation of Korea [과06A2101] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the present study, we sought to determine whether bee venom (BV) promotes the survival of dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD). Treatment with BV prevented degeneration of DA neurons in the substantia nigra (SN). This neuro-protective effect of BV was associated with microglial deactivation and reduction of CD4 T cell infiltration. Additionally, BV treatment significantly increased the proportion of CD4(+)CD25(+)Foxp3(+) Tregs in vivo and in vitro. The increased proportion of Tregs by BV treatment remained suppressive ex vivo. Interestingly, BV treatment did not prevent MPTP neurotoxicity in mice depleted of Tregs by anti-CD25 antibody injection. Therefore, our present studies suggest that modulation of peripheral immune tolerance by Treg may contribute to the neuroprotective effect of By in the MPTP model of Parkinson's disease. (C) 2012 Elsevier Inc. All rights reserved.
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