Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 25, Issue 1, Pages 46-52Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2010.07.243
Keywords
Social disruption stress; Dendritic cell; Influenza A; CD8(+) T cells
Categories
Funding
- NIH [NIMH/RO1MH046801-16, NIDCR/T 32DE014320-6]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [T32DE014320] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH046801] Funding Source: NIH RePORTER
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Dendritic cells (DCs) sample their surrounding microenvironment and consequently send immunogenic or regulatory signals to T cells during DC/T cell interactions, shaping the primary adaptive immune response to infection. The microenvironment resulting from repeated social defeat increases DC co-stimulatory molecule expression and primes DCs for enhanced cytokine responses in vitro. In this study, we show that social disruption stress (SDR) results in the generation of immunogenic DCs, capable of conferring enhanced adaptive immunity to influenza A/PR/8/34 infection. Mice infected with influenza A/PR/8/34 virus 24 h after the adoptive transfer of DCs from SDR mice had significantly increased numbers of D(b)NP(366-74)CD8(+) T cells, increased IFN-gamma and IFN-alpha mRNA, and decreased influenza M1 mRNA expression in the lung during the peak primary response (9 days post-infection), compared to mice that received DCs from naive mice. These data demonstrate that repeated social defeat is a significant environmental influence on immunogenic DC activation and function. (C) 2010 Elsevier Inc. All rights reserved.
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