Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 24, Issue 1, Pages 119-126Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2009.09.002
Keywords
IL-6; Brain; Body weight; ITT; OGTT; Fat diet; Neuroinflammation
Categories
Funding
- European Commission [LSHM-CT-2004-005272, SAF2008-00435,]
- RETICS [RD07/0060/0002]
- Danish National Research Foundation [02-512-55]
- Capital Region of Denmark
- University of Copenhagen
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Interleukin-6 (IL-6) is a major cytokine involved in both normal physiological brain functions and underlying significant neuropathology. IL-6 has been suggested to play a role in the control of body weight but the results are somewhat controversial. In this study we have challenged transgenic mice with astrocyte-targeted IL-6 expression (GFAP-IL6 mice) with a high-fat diet (55% kcal from fat) versus a control diet (10%). The results demonstrate that the GFAP-IL6 mice are resistant to high-fat diet-induced increases in body weight and body fat, apparently without altering food intake and with no evidences of increased sympathetic tone. The high-fat diet-induced impaired responses to an insulin tolerance test (ITT), and to an oral glucose tolerance test (OGTT) in both genotypes. The GFAP-IL6 mice did not differ from littermate wild-type (WT) mice in ITT, but they were more glucose intolerant following the high-fat diet feeding. In summary, the present results demonstrate that brain-specific IL-6 controls body weight which may be a significant factor in physiological conditions and/or in diseases causing neuroinflammation. (C) 2009 Elsevier Inc. All rights reserved.
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