Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 23, Issue 3, Pages 389-395Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2008.12.005
Keywords
Autism; Immunology; Antibodies; Immunoglobulin; IgG4; Behavior; ADOS
Categories
Funding
- NIEHS [P01 ES11269, RO1 ES015359]
- U.S. EPA STAR program [R829388]
- Cure Autism Now
- Ted Lindsay Cure Autism Now Foundation
- Peter Emch Foundation
- Johnson Family
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES015359, P01ES011269] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Accumulating evidence indicates that immune dysfunction is associated with autism disorders in a significant subset of children. Previous reports have shown abnormal immunoglobulin (Ig) levels, including an increased presence of autoreactive antibodies in the circulation of individuals with autism. As IgG is the predominant antibody isotype in circulation, we expected that an altered immune response could result in an abnormal IgG subclass profile in children with autism. We examined circulating plasma levels of IgG1, IgG2, IgG3, and IgG4 in 241 children from the CHARGE (Childhood Autism Risks from Genetics and the Environment) study, a large epidemiologic case-control investigation, including 114 children who meet full criteria for autism disorder (AU), 96 typically developing control children (TD) from a randomly selected sample of the general population, and 31 children with developmental delays (DD). We report significantly increased levels of the IgG4 subclass in children with AU compared with TD control children (p = 0.016) and compared with DD controls (p = 0.041). These results may suggest an underlying immunological abnormality in AU subjects resulting in elevated IgG4 production. Further investigation is necessary to elucidate the relationship between immunological findings and behavioral impairments in autism. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available