Journal
BRAIN AND LANGUAGE
Volume 119, Issue 3, Pages 206-213Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2011.07.005
Keywords
TMS; Brain stimulation; Aphasia; Stroke rehabilitation
Funding
- NIH [RO1 DC05672, RRO18875, P30 DC05207]
- National Institute on Deafness and Other Communication Disorders, Bethesda, MD
- Medical Research Service, Department of Veterans Affairs, Washington, D.C.
- BBVA Chair in Translational Medicine, Harvard Clinical and Translational Science Center [UL1 RR025758, RO1-NS 47754, RO1-NS 20068]
- Harvard-Thorndike General Clinical Research Center [NCRR MO1 RR01032]
- National Institute on Deafness and Other Communication Disorders
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This study sought to discover if an optimum 1 cm(2) area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. Published by Elsevier Inc.
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