Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 9, Issue 10, Pages 1315-1330Publisher
TAYLOR & FRANCIS INC
DOI: 10.1586/ERC.11.120
Keywords
carotid atherosclerosis; carotid endarterectomy; diagnostic studies; medical therapy; stenting; stroke
Categories
Funding
- Merck
- Novartis
- NIH [R44-HL070576]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R44HL070576] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Carotid atherosclerotic plaques represent both stable and unstable atheromatous lesions. Atherosclerotic plaques that are prone to rupture owing to their intrinsic composition such as a large lipid core, thin fibrous cap and intraplaque hemorrhage are associated with subsequent thromboembolic ischemic events. At least 15- 20% of all ischemic strokes are attributable to carotid artery atherosclerosis. Characterization of plaques may enhance the understanding of natural history and ultimately the treatment of atherosclerotic disease. MRI of carotid plaque and embolic signals during transcranial Doppler have identified features beyond luminal stenosis that are predictive of future transient ischemic attacks and stroke. The value of specific therapies to prevent stroke in symptomatic and asymptomatic patients with severe carotid artery stenosis are the subject of current research and analysis of recently published clinical trials that are discussed in this article.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available