Journal
BIOINFORMATION
Volume 5, Issue 7, Pages 285-290Publisher
BIOMEDICAL INFORMATICS
DOI: 10.6026/97320630005285
Keywords
Oral lichen planus; oral squamous cell carcinoma; proteomic voting; tumor microenvironment; T cell lineages; tumor immune surveillance
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Funding
- University of California Senate
- UCLA School of Dentistry
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The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O'Shea & Paul, 2010 [4]). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.
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