Journal
BRAIN AND COGNITION
Volume 79, Issue 1, Pages 49-59Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandc.2011.12.011
Keywords
Go/no-go task; Development; Magnetoencephalography (MEG); Inhibitory control; Inferior frontal gyri
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Funding
- Canadian Institutes of Health Research [MOP-81161]
- Foundation Orange (France)
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Inhibition is a core executive function reliant on the frontal lobes that shows protracted maturation through to adulthood. We investigated the spatiotemporal characteristics of response inhibition during a visual go/no-go task in 14 teenagers and 14 adults using magnetoencephalography (MEG) and a contrast between two no-go experimental conditions designed to eliminate a common confound in earlier studies comparing go with no-go trials. Source analyses were performed using an event-related beam-former algorithm with co-registered individual structural MRIs. Performance was controlled to be similar across subjects. Analyses of MEG data revealed bilateral prefrontal activity in the inhibitory condition for both age groups, but with different spatiotemporal patterns: around 300 ms after stimulus onset in middle frontal gyri in teenagers vs. around 260 ms in inferior frontal gyri in adults. Moreover, the inhibition of a prepotent motor response showed a stronger recruitment of the left hemisphere in teenagers than in adults and of the right hemisphere in adults than in teenagers. These findings provide high-resolution temporal and spatial information regarding response inhibition in adolescents compared to adults, independent of motor components and performance differences. (c) 2012 Elsevier Inc. All rights reserved.
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