Journal
BRAIN AND COGNITION
Volume 72, Issue 1, Pages 26-35Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandc.2009.06.002
Keywords
MRI; DTI; MTR; g ratio; Schizophrenia; ADHD; Cytoskeleton; Axonal transport
Categories
Funding
- Canadian Institutes of Health Research
- Royal Society (United Kingdom)
- National Institutes of Health (United States)
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White matter occupies almost half of the human brain. It contains axons connecting spatially segregated modules and, as such, it is essential for the smooth flow of information in functional networks. Structural maturation of white matter continues during adolescence, as reflected in age-related changes in its volume, as well as in its microstructure. Here I review recent observations obtained with magnetic resonance imaging in typically developing adolescents and point out some of the known variations in structural properties of white matter vis-A-vis brain function in health and disease. I conclude by refocusing the interpretations of MR-based studies of white matter from myelin to axon. (C) 2009 Elsevier Inc. All rights reserved.
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