Journal
BRAIN AND COGNITION
Volume 73, Issue 2, Pages 146-151Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandc.2010.04.007
Keywords
Working memory; Magnetic resonance imaging; Cardiovascular disease; Endothelium; Middle-aged; Cognition
Categories
Funding
- NINR [P30 NR005051]
- AHA [09BGIA2060722]
- University of Texas at Austin
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The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (beta = 0.338, p = 0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36) = 2.66, p = 0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted. (C) 2010 Elsevier Inc. All rights reserved.
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