Journal
BRAIN & DEVELOPMENT
Volume 34, Issue 5, Pages 337-343Publisher
ELSEVIER
DOI: 10.1016/j.braindev.2011.07.012
Keywords
Acute encephalopathy; Epidemiology; Acute necrotizing encephalopathy; Acute encephalopathy with biphasic seizures and late reduced diffusion; Clinically mild encephalitis/encephalopathy with a reversible splenial lesion
Categories
Funding
- Ministry of Health, Labour and Welfare, Japan [H22-Nanji-Ippan-49, 21B-5, 21210301, KB220001]
- Japan Society for the Promotion of Science [21249062, 20209753, 22591176]
- Japan Science and Technology Agency
- Japan Epilepsy Research Foundation
- Grants-in-Aid for Scientific Research [23591518, 21200017, 22591176] Funding Source: KAKEN
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A research committee supported by the Japanese government conducted a nationwide survey on the epidemiology of acute encephalopathy in Japan using a questionnaire. A total of 983 cases reportedly had acute encephalopathy during the past 3 years, 2007-2010. Among the pathogens of the preceding infection, influenza virus was the most common, followed by human herpesvirus-6 (HHV-6) and rotavirus. Among syndromes of acute encephalopathy, acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) was the most frequent, followed by clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS), acute necrotizing encephalopathy (ANE) and hemorrhagic shock and encephalopathy syndrome (HSES). Influenza virus was strongly associated with ANE and MERS, HHV-6 with AESD, and rotavirus with MERS. Mortality was high in ANE and HSES, but was low in AESD, MERS and HHV-6-associated encephalopathy. Neurologic sequelae were common in AESD and ANE, but were absent in MERS. (C) 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
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