Journal
BRAIN & DEVELOPMENT
Volume 31, Issue 9, Pages 666-670Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2008.10.007
Keywords
Neonatal treatment; Transgenerational effect; Vitamins; Biogenic amines; Imprinting
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Funding
- Ministry of Health [ETT 343/2006]
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Biogenic amines (norepinephrine, dopamine, homovanillic acid, serotonin and 5-hyroxyindole acetic acid) were measured by HPLC method in adult F1 generation rats' brain regions (brainstem, hypothalamus, hippocampus, striatum and frontal cortex), whose mothers (P generation) were treated with vitamin A or vitamin D neonatally (hormonal imprinting). Many significant differences were found, related to the maternally untreated controls. In the earlier studied P generation females, vitamin A consistently influenced the serotonerg system (5HIAA), while vitamin D the dopaminerg system (DA or HVA). Vitamin A imprinting always resulted in reduced, while that by vitamin D always in increased tissue levels. In the present case (directly untreated F1 generation) the transgenerational effect was not unidirectional, however biogenic amine tissue levels were strongly disturbed and brain-area dependent. The results call attention to the transgenerational effect of hormonal imprinting in the case of receptor level acting vitamins which are frequently used in the most imprinting-sensitive period (perinatally) of human life and suggests that caution is warranted. (C) 2008 Elsevier B.V. All rights reserved.
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