Journal
BRAIN & DEVELOPMENT
Volume 30, Issue 1, Pages 86-90Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2007.05.013
Keywords
hemiplegic migraine; intravenous verapamil; cerebral perfusion
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A 20-year-old female with hemiplegic migraine was treated during an acute attack with intravenous verapamil, which reproducibly resolved the headache within 20 min but did not affect her hemiplegia. Magnetic resonance (MR) and computed tomographic (CT) angiography and perfusion performed during the attack showed vasodilation and hyperperfusion. Cerebral hyperperfusion concurrent with hemiplegia suggests a dissociation between cerebral perfusion and neuronal function in hemiplegic migraine. The beneficial effect of verapamil on headache but not hemiplegia suggests a distinct mechanism for pain and neuronal dysfunction in hemiplegic migraine, with the beneficial effect on pain not due to vasodilation. (c) 2007 Elsevier B.V. All rights reserved.
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