Journal
BRAIN
Volume 134, Issue -, Pages 3432-3450Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awr064
Keywords
neuropsychiatric disorders; neurological disorders; central auditory processing; cognitive decline; mismatch negativity (MMN)
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Funding
- Estonian Science Foundation [8332]
- National Centres of Excellence [20062011, 214412]
- Academy of Finland [122745]
- Great Ormond Street Hospital Children's Charity
- Spanish Ministry of Science and Innovation [CSD2007-00012, EUI2009-04806, PSI2009-08063]
- Generalitat de Catalunya [SGR2009-11]
- [128840]
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Cognitive impairment is a core element shared by a large number of different neurological and neuropsychiatric diseases. Irrespective of their different aetiologies and symptomatologies, most appear to converge at the functional deficiency of the auditory-frontal cortex network of auditory discrimination, which indexes cognitive impairment shared by these abnormalities. This auditory-frontal cortical deficiency, and hence cognitive decline, can now be objectively measured with the mismatch negativity and its magnetic equivalent. The auditory-frontal cortical network involved seems, therefore, to play a pivotal, unifying role in the different abnormalities. It is, however, more likely that the dysfunction that can be detected with the mismatch negativity and its magnetoencephalographic equivalent manifests a more widespread brain disorder, namely, a deficient N-methyl-d-aspartate receptor function, shared by these abnormalities and accounting for most of the cognitive decline.
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