Journal
BRAIN
Volume 134, Issue -, Pages 1168-1183Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awr030
Keywords
human neural progenitor cells; oligodendrocyte; migration; oligodendrogenesis; remyelination
Categories
Funding
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Universite Pierre et Marie Curie, European Leucodystrophy Association (ELA)
- National Multiple Sclerosis Society (NMSS, USA)
Ask authors/readers for more resources
Improving oligodendroglial differentiation from human foetal neural progenitor cells remains a primordial issue to accomplish successful cell-based therapies in myelin diseases. Here, we combined in situ, in vitro and in vivo approaches to assess the oligodendrogenic potential of different human foetal forebrain regions during the first trimester of gestation. We show for the first time that the initial wave of oligodendrocyte progenitor emergence in the ventral telencephalon onsets as early as 7.5 weeks into gestation. Interestingly, in vitro, isolation of ganglionic eminences yielded oligodendrocyte progenitor-enriched cultures, as compared with cortex and thalamus. Most importantly, single injection of human neural progenitors into rodent models of focal gliotoxic demyelination revealed the great capacity of these cells to survive, extensively migrate and successfully remyelinate the spinal cord, irrespective of their origin. Thus, our study brings novel insights into the biology of early human foetal neural progenitor cells and offers new support for the development of cellular therapeutics for myelin disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available