Journal
BRAIN
Volume 133, Issue -, Pages 2789-2797Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awq190
Keywords
epilepsy; seizure; intracranial EEG; microseizure; microcircuit; seizure generation; ictogenesis; epileptogenesis
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Funding
- National Institutes of Health [R01-NS063039, R01-NS48598, NS041811]
- Mayo Clinic Discovery Translation Grant
- Minnesota Partnership for Biotechnology and Medical Genomics
- CURE Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS041811, R01NS048598, R01NS063039] Funding Source: NIH RePORTER
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Focal seizures appear to start abruptly and unpredictably when recorded from volumes of brain probed by clinical intracranial electroencephalograms. To investigate the spatiotemporal scale of focal epilepsy, wide-bandwidth electrophysiological recordings were obtained using clinical macro- and research microelectrodes in patients with epilepsy and control subjects with intractable facial pain. Seizure-like events not detectable on clinical macroelectrodes were observed on isolated microelectrodes. These 'microseizures' were sparsely distributed, more frequent in brain regions that generated seizures, and sporadically evolved into large-scale clinical seizures. Rare microseizures observed in control patients suggest that this phenomenon is ubiquitous, but their density distinguishes normal from epileptic brain. Epileptogenesis may involve the creation of these topographically fractured microdomains and ictogenesis (seizure generation), the dynamics of their interaction and spread.
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