Journal
BRAIN
Volume 134, Issue -, Pages 359-374Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awq332
Keywords
deep brain stimulation; magnetoencephalograhy; subthalamic nucleus; Parkinson's disease; functional connectivity
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Funding
- Parkinson's UK
- Marie Curie Intra European fellowship [MEIF-CT-2006 038858]
- British Technion Society
- Medical Research Council
- Rosetrees Trust
- NIHR Biomedical Research Centre, Oxford
- Wellcome Trust
- MRC [G0901503] Funding Source: UKRI
- Medical Research Council [G0901503] Funding Source: researchfish
- Parkinson's UK [F-0903] Funding Source: researchfish
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Both phenotype and treatment response vary in patients with Parkinson's disease. Anatomical and functional imaging studies suggest that individual symptoms may represent malfunction of different segregated networks running in parallel through the basal ganglia. In this study, we use a newly described, electrophysiological method to describe cortico-subthalamic networks in humans. We performed combined magnetoencephalographic and subthalamic local field potential recordings in thirteen patients with Parkinson's disease at rest. Two spatially and spectrally separated networks were identified. A temporoparietal-brainstem network was coherent with the subthalamic nucleus in the alpha (7-13 Hz) band, whilst a predominantly frontal network was coherent in the beta (15-35 Hz) band. Dopaminergic medication modulated the resting beta network, by increasing beta coherence between the subthalamic region and prefrontal cortex. Subthalamic activity was predominantly led by activity in the cortex in both frequency bands. The cortical topography and frequencies involved in the alpha and beta networks suggest that these networks may be involved in attentional and executive, particularly motor planning, processes, respectively.
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