Journal
BRAIN
Volume 134, Issue -, Pages 293-300Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awq310
Keywords
Alzheimer's disease; PET imaging; genetics
Categories
Funding
- Department of Health's National Institute for Health Research (NIHR) Biomedical Research Centres
- Medical Research Council UK
- Medical Research Council [G84/6523, G0900421, MC_U120036861, G1100810, G0601846, G1100809, MC_U120085814, G0801306] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10123] Funding Source: researchfish
- MRC [G84/6523, MC_U120085814, G0601846, G0801306, G0900421, G1100810, MC_U120036861, G1100809] Funding Source: UKRI
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(11)Carbon-Pittsburgh compound B positron emission tomography studies have suggested early and prominent amyloid deposition in the striatum in presenilin 1 mutation carriers. This cross-sectional study examines the (11)Carbon-Pittsburgh compound B positron emission tomography imaging profiles of presymptomatic and mildly affected (mini-mental state examination epsilon 20) carriers of seven presenilin 1 mutations, comparing them with groups of controls and symptomatic sporadic Alzheimer's disease cases. Parametric ratio images representing (11)Carbon-Pittsburgh compound B retention from 60 to 90 min were created using the pons as a reference region and nine regions of interest were studied. We confirmed that increased amyloid load may be detected in presymptomatic presenilin 1 mutation carriers with (11)Carbon-Pittsburgh compound B positron emission tomography and that the pattern of retention is heterogeneous. Comparison of presenilin 1 and sporadic Alzheimer's disease groups revealed significantly greater thalamic retention in the presenilin 1 group and significantly greater frontotemporal retention in the sporadic Alzheimer's disease group. A few individuals with presenilin 1 mutations showed increased cerebellar (11)Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer's disease.
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