Journal
BRACHYTHERAPY
Volume 10, Issue 3, Pages 242-248Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brachy.2010.09.001
Keywords
Cervical cancer; Locally advanced; Interstitial brachytherapy; High-dose rate; Weekly schedule
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PURPOSE: To evaluate the feasibility of high dose rate interstitial brachytherapy (HDR-IBT) using two weekly sessions of 10 Gy in combination to pelvic external beam radiation therapy (EBRT) for patients with locally advanced cervical carcinoma. METHODS AND MATERIALS: Between the year 2005 and 2007, 42 patients with locally advanced cervical carcinoma (International Federation of Gynecology and Obstetrics Stage IIB-IVA), not suitable for intracavitary radiotherapy after completing EBRT, were enrolled in this prospective study. Two weekly sessions of HDR-IBT with 10 Gy each were delivered 1 week after pelvic EBRT. Various parameters studied for evaluating the feasibility were procedure-related complications, delayed radiation toxicity, and recurrence-free survival. RESULTS: International Federation of Gynecology and Obstetrics stage distribution of patients was as follows: Stage IIB (10), Stage IIIB (27), and Stage IVA (5). A total of 84 HDR-IBT procedures were performed in these 42 patients. Each session of brachytherapy treatment (from needle insertion to removal of template) was completed in less than 4 h. Frequency of various procedure-related complications were as follows: hematuria (3.5%), deep vein thrombosis (0%), and visceral puncture (0%). Overall delayed radiation toxicity (Grade III-IV) was 9%. Median followup was 23 months. The 3-y overall survival for all stages was 47% and the 3-y recurrence-free survival for stage IIB, IIIB, and IVA was 67%, 34%, and 20%, respectively. CONCLUSION: Our clinical results have shown that weekly HDR-IBT schedule (10 Gy x 2) is associated with low toxicity, decent local control, and survival rates thereby proving its clinical feasibility. (C) 2011 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
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