Journal
PARKINSONS DISEASE
Volume 2011, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.4061/2011/967839
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Funding
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [NS038367]
- Veterans Administration through its Southwest Parkinson's Disease Research, Education, and Clinical Center (PADRECC)
- NIA [P30AG021684, P30-AG028748]
- NCMHD [2P20MD000182]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS038367] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG021684] Funding Source: NIH RePORTER
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We assessed degree of Parkinson disease motor symptom improvement with medication among subjects enrolled in an ongoing, population-based study in Central California. The motor section of the unified Parkinson disease rating scale (UPDRS) was performed on subjects in both OFF and ON medication states, and difference between these scores was used as an indicator of symptomatic benefit. Higher OFF minus ON scores correlated with more severe baseline symptoms. There was equivalent improvement on the motor UPDRS scale for subjects divided according to medication classes used: levodopa alone 7.3 points, levodopa plus other medications 8.5 points, and dopamine agonists but not levodopa 6.1 points. In addition, there was no difference in the magnitude of improvement when subjects were divided according to Parkinson disease subtype, defined as tremor dominant, akinetic-rigid, or mixed. In this community-based sample, these values are within the range of a clinically important difference as defined by previous studies.
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