Journal
TRANSCRIPTION-AUSTIN
Volume 2, Issue 3, Pages 115-119Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.2.3.15004
Keywords
transcription; RNA polymerase II; CTD kinase; C-terminal repeat domain; P-TEFb; CDK12; CDK13
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Funding
- NIH [GM040505]
- Duke School of Medicine Bridging Funds
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM040505] Funding Source: NIH RePORTER
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The C-terminal domain of RNA poly II undergoes a cycle of phosphorylation which allows it to temporally couple transcription with transcription associated processes. The characterization of hitherto unrecognized metazoan elongation phase CTD kinase activities expands our understanding of this coupling. We discuss the circumstances that delayed the recognition of these kinase activities.
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