Journal
TRANSCRIPTION-AUSTIN
Volume 2, Issue 2, Pages 91-94Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.2.2.14962
Keywords
chromatin; heat shock; protein homeostasis; protein misfolding; protein degradation
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Uehara Memorial Fundation
- Takeda Foundation
- Yamaguchi University Research Project on STRESS
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The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in cooperation with the transcription factor NFAT.
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