Journal
PHARMACOGNOSY RESEARCH
Volume 3, Issue 1, Pages 30-34Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/0974-8490.79112
Keywords
Ficus religiosa; inflammation; TNF-alpha; type 2 diabetes
Categories
Ask authors/readers for more resources
Background: Chronic systemic inflammation is an early process in pathogenesis of type 2 diabetes. Hence the present study was aimed to investigate the effect of traditionally known plant Ficus religiosa on elevated glucose and inflammatory marker namely tumor necrosis factor (TNF)-alpha in type 2 diabetic rats. Methods: Type 2 diabetes was induced by administering streptozotocin (90 mg/kg, i.p.) in neonatal rat model. Aqueous extract of F. religiosa at a dose of 100 and 200 mg/kg was given orally to desired group of animals for a period of 4 weeks. After 4 weeks of drug treatment, parameters such as fasting blood glucose, postprandial blood glucose and TNF-alpha in serum were analyzed. Results: Aqueous extract of F. religiosa at both dose levels i.e., 100 and 200 mg/kg decreased the elevated glucose and TNF-alpha in type 2 diabetic rats. The extract at 200 mg/kg had more pronounced effect. Conclusion: Modulation of cytokine TNF-alpha by the aqueous extract of F. religiosa indicates that the anti-inflammatory and immunomodulatory property of the plant is related with its potential anti-diabetic activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available