Journal
TRANSCRIPTION-AUSTIN
Volume 2, Issue 1, Pages 19-22Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.2.1.13650
Keywords
MITF; melanocyte; epigenetic; gene regulation; lineage specific
Categories
Funding
- NIAMS NIH HHS [R01 AR043369] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR043369] Funding Source: NIH RePORTER
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Microphthalmia-associated transcription factor, MITF, is a master regulator of melanocyte development, differentiation, migration and survival. 1 A broad collection of studies have indicated that MITF directly regulates the transcription of genes involved in pigmentation, which are selective to the melanocyte lineage. In addition, MITF controls expression of genes which are expressed in multiple cell lineages and may also play differential roles in activating vs. maintaining gene expression patterns. In this Point-of-View article, we discuss lineage restricted transcription factor activation of both tissue-specific and ubiquitously expressed genes using melanocytes and MITF as a model system that may eventually provide insights into such processes in multiple cell lineages.
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