Journal
BONE MARROW TRANSPLANTATION
Volume 48, Issue 3, Pages 376-382Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2012.176
Keywords
cord blood transplantation; BMT; lymphocyte subpopulations; immune reconstitution; thymopoiesis
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Funding
- Fonds de Recherche en Sante du Quebec
- Fondation Charles-Bruneau
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Some clinical characteristics of cord blood transplantation (CBT) might be explained by specificities in the reconstitution of immune subsets differing by their maturation stage or their implication in GVHD, tolerance or immune responses against tumor or infectious agents. Here, we compare the immune reconstitution of several of these subsets after CBT and BMT. B-cell count recovery was faster after CBT. There was no difference in the recovery of CD4(+) and CD8(+) cell counts. There was no difference either in the frequency of several subsets: CD45RO(+) memory, and CD45RA(+) naive cells within the CD4(+) T-cell compartment, CD27(+) among B cells, CD56(bright), NKG2A(+), and KIR+ cells among natural killer (NK) cells, CD25(+)FOXP3(+) regulatory T cells and invariant NKT cells. The proportion of the thymic naive CD31(+)CD45RA(+)CD4(+) T cells was lower after CBT at 6 months post-transplant, and was still below normal at 1 year in both groups. NK-cell expansion was more sustained after CBT, with fewer double-negative NKG2A(-)KIR(-) hyporesponsive cells and more double-positive NKG2A(+) KIR+ hyper-responsive NK cells. These results, therefore, indicate that further research to improve CBT outcome should try to improve thymopoieisis and take advantage of the sustained NK-cell reconstitution. Bone Marrow Transplantation (2013) 48, 376-382; doi: 10.1038/bmt.2012.176; published online 15 October 2012
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