Journal
BONE MARROW TRANSPLANTATION
Volume 47, Issue 12, Pages 1552-1557Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2012.63
Keywords
reduced-intensity conditioning; lymphoma; sirolimus; GVHD
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Funding
- Intramural NIH HHS [Z01 BC010698] Funding Source: Medline
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Reduced-intensity conditioning (RIC) allo-SCT is a potentially curative treatment approach for patients with relapsed Hodgkin's or non-Hodgkin's lymphoma. In the present study, 37 patients underwent RIC allo-SCT after induction treatment with EPOCH-F(R) using a novel form of dual-agent immunosuppression for GVHD prophylaxis with CsA and sirolimus. With a median follow-up of 28 months among survivors, the probability for OS at 3 and 5 years was 56%. Treatment-related mortality was 16% at day +100 and 30% after 1 year of transplant. Acute GVHD grades II-IV developed in 38% of patients, suggesting that the regimen consisting of CsA and an ultra-short course of sirolimus is effective in the prevention of acute GVHD. Bone Marrow Transplantation (2012) 47, 1552-1557; doi:10.1038/bmt.2012.63; published online 23 April 2012
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