Journal
TRANSCRIPTION-AUSTIN
Volume 2, Issue 2, Pages 82-85Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.2.2.14807
Keywords
DNA topology; topoisomerase; silencing; DNA twist; DNA unwinding; positive supercoil; chromatin architecture
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Funding
- Xarxa de Referencia en Biotecnologia de la Generalitat de Catalunya
- [BFU2008-00366]
- [AGAUR 2009 SGR01222]
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Most genome transactions are favored by DNA (-) torsional stress, i.e., unconstrained unwinding or supercoiling of DNA. A question raised here is whether DNA (+) torsional stress, which precludes DNA unwinding, could also be relevant in gene regulation. Such DNA twist dynamics could be determined by chromatin architecture.
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