Journal
DERMATO-ENDOCRINOLOGY
Volume 3, Issue 3, Pages 211-215Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/derm.17027
Keywords
thyroid hormone; skin; epidermis; dermis; cutaneous
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The skin characteristics associated with thyroid hormone are classic. The name myxedema refers to the associated skin condition caused by increased glycosaminoglycan deposition in the skin. Generalized myxedema is still the classic cutaneous sign of hypothyroidism. It is caused by deposition of dermal acid mucopolysaccharides, notably hyaluronic acid. Despite its appearance, the skin does not pit with pressure.
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