From the bench to the clinic New aspects on immunoregulation by vitamin D analogs

The skin is a vital organ that plays a crucial role in defending us from pathogens. Multiple players from the innate and adaptive immune system are involved, such as neutrophils, dendritic cells, lymphocytes and antimicrobial peptides. Chronic inflammatory skin diseases can be mediated by inflammatory T cells and their interactions with other cells in the skin. Vitamin D is generated in the skin upon sun exposure and has a variety of effects. Vitamin D and its analogs have been used with success in treating mild to moderate T cell-mediated skin diseases, but how they mediate the beneficial effects is not well understood. In the recent years, emerging evidence is rising that vitamin D analogs and its modulation on the immune system plays a major role. It has been shown that vitamin D analogs can induce the generation of regulatory T cells, which are able to suppress proliferation and alter the function of inflammatory T cells. This may help explain the therapeutic effects that are observed and at the same time give hope that in combination with other therapy or used alone, vitamin D analogs may be helpful when treating more severe forms of the diseases.