Journal
TRANSCRIPTION-AUSTIN
Volume 2, Issue 4, Pages 189-192Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.2.4.16565
Keywords
chromatin; signaling kinases; transcription; inducible genes; T cell; immune system; microRNAs
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We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-theta). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design.
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