Journal
BONE MARROW TRANSPLANTATION
Volume 46, Issue 7, Pages 987-992Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2010.221
Keywords
polyomavirus JC; progressive multifocal leukoencephalopathy; allogeneic transplantation; adoptive immunotherapy; CTL; GVHD
Categories
Funding
- AIRC (Associazione Italiana Ricerca sul Cancro)
- Regione Lombardia
- MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca)
- Ministero della Salute, Progetti Ricerca Oncologica [RFPS-2006-4-341763, RFPS-2006-2-340145, RFPS-2006-Regione Umbria]
- Fondazione Cariplo
- Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Policlinico San Matteo
- Fondazione Malattie Renali del Bambino, Genova, Italy
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Progressive multifocal leukoencephalopathy (PML) associated with polyomavirus JC (JCV) infection has been reported to be usually fatal in allogeneic hematopoietic SCT (HSCT) recipients. We present the case of a 19-year-old HSCT patient diagnosed with JCV-associated PML after prolonged immunosuppression for severe GVHD. No short-term neurological improvement was observed after antiviral treatment and discontinuation of immunosuppressive therapy. Donor-derived JCV Ag-specific CTLs were generated in vitro after stimulation with 15-mer peptides derived from VP1 and large T viral proteins. After adoptive CTL infusion, virus-specific cytotoxic cells were shown in the peripheral blood, JCV-DNA was cleared in the cerebrospinal fluid and the patient showed remarkable improvement. Adoptive T-lymphocyte therapy with JCV-specific CTLs was feasible and had no side effects. This case suggests that adoptive transfer of JCV-targeted CTLs may contribute to restore JCV-specific immune competence and control PML in transplanted patients. Bone Marrow Transplantation (2011) 46, 987-992; doi: 10.1038/bmt.2010.221; published online 4 October 2010
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