Journal
BONE MARROW TRANSPLANTATION
Volume 46, Issue 1, Pages 116-118Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2010.92
Keywords
adult T-cell leukemia/lymphoma; allogeneic hematopoietic SCT; reduced-intensity conditioning regimen; HTLV-1 proviral load
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We have previously conducted clinical trials of allogeneic hematopoietic SCT with reduced-intensity conditioning regimen (RIC) for adult T-cell leukemia/lymphoma (ATLL)-a disease caused by human T-lymphotropic virus type 1 (HTLV-1) infection and having a dismal prognosis. Long-term follow-up studies of these trials revealed that 10 of the 29 patients have survived for a median of 82 months (range, 54-100 months) after RIC, indicating a possible curability of the disease by RIC. However, we have also observed that the patterns of post-RIC changes in HTLV-1 proviral load over time among the 10 survivors were classified into three patterns. This is the first report to clarify the long-term outcomes after RIC for ATLL patients. Bone Marrow Transplantation (2011) 46, 116-118; doi:10.1038/bmt.2010.92; published online 19 April 2010
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