Journal
GUT MICROBES
Volume 2, Issue 1, Pages 58-60Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.2.1.14911
Keywords
gastroenteritis; salmonella; inflammation; microbiota; tetrathionate
Categories
Funding
- Public Health Service [AI040124, AI044170, AI073120, AI076246, AI079173, AI088122]
Ask authors/readers for more resources
Salmonella is a common cause of food poisoning. However, after ingestion the pathogen has to compete with resident microbes that already occupy the intestinal lumen (microbiota), which poses a challenge for Salmonella to successfully colonize this niche. Recent data show that Salmonella elicits help from the host immune response to beat the competition. After arriving in the intestine, Salmonella elicits acute intestinal inflammation. The respiratory burst of neutrophils that transmigrate into the intestinal lumen during inflammation oxidizes endogenous sulfur compounds to generate a respiratory electron acceptor, tetrathionate. As a result, Salmonella can use tetrathionate respiration to outgrow the fermenting microbiota in the anaerobic environment of the gut, which promotes transmission of the pathogen. This principle might be used by other gut microbes and contribute to changes in the microbiota composition observed during inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available