Journal
BONE MARROW TRANSPLANTATION
Volume 45, Issue 1, Pages 153-158Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bmt.2009.99
Keywords
acute kidney injury; risk factors; nonmyeloablative allogeneic hematopoietic SCT
Categories
Funding
- Jiangsu Provincial Key Medical Talent [RC 2007072]
Ask authors/readers for more resources
Acute kidney injury (AKI) is a common early complication in patients with hematopoietic SCT (HSCT). However, there are limited data about the incidence and risk factors of AKI in patients with nonmyeloablative HSCT. We conducted a multicenter, retrospective cohort study of 62 patients from three institutions who were treated with similar protocols for nonmyeloablative HSCT. AKI was classified according to the Acute Kidney Injury Network criteria. It was shown that 29% of the patients developed AKI in the first 100 days after nonmyeloablative HSCT. The risk factor at baseline for AKI was incomplete HLA-matched transplant (odds ratio (OR) 3.6; 95% confidence interval (CI) 1.1-13.0). Complications such as acute GVHD, veno-occlusive disease of liver and sepsis were also associated with the development of AKI (OR 12.1; 95% CI 2.4-62.4). AKI was significantly associated with mortality (OR = 4.7; 95% CI 1.9-11.5). We concluded that AKI is a very common complication in patients with nonmyeloablative HSCT, which is associated with incomplete HLA-matched transplant and complications, and has an important impact on the patients' first year of survival. Bone Marrow Transplantation (2010) 45, 153-158; doi: 10.1038/bmt.2009.99; published online 11 May 2009
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available