Journal
JOURNAL OF NUCLEIC ACIDS
Volume 2011, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.4061/2011/756905
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Funding
- NIH/NCRR/OD UCSF-CTSI [KL2 RR024130]
- PhRMA Foundation Predoctoral Informatics Fellowship
- Howard Hughes Medical Institute
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Papillomaviruses have been implicated in a variety of human diseases ranging from common warts to invasive carcinoma of the anogenital mucosa. Existing assays for genotyping human papillomavirus are restricted to a small number of types. Here, we present a comprehensive, accurate microarray strategy for detection and genotyping of 102 human papillomavirus types and validate its use in a panel of 91 anal swabs. This array has equal performance to traditional dot blot analysis with the benefits of added genotype coverage and the ability to calibrate readout over a range of sensitivity or specificity values.
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