Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 32, Pages 17765-17775Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b03998
Keywords
multimodal imaging contrast agent; MRI/CT; gold nanoparticles; gadolinium metal organic framework nanoparticles
Funding
- State of Colorado
- Colorado School of Mines
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Imaging contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT) have received significant attention in the development of techniques for early stage cancer diagnosis. Gadolinium (Gd)(III), which has seven unpaired electrons and a large magnetic moment, can dramatically influence the water proton relaxation and hence exhibits excellent MRI contrast. On the other hand, gold (Au), which has a high atomic number and high X-ray attenuation coefficient, is an ideal contrast agent candidate for X-ray-based CT imaging. Gd metal organic framework (MOF) nanopartides with tunable size, high Gd(III) loading and multivalency can potentially overcome the limitations of clinically utilized Gd chelate contrast agents. In this work, we report for the first time the integration of GdMOF nanopartides with gold nanopartides (AuNPs) for the preparation of a MRI/CT bimodal imaging agent. Highly stable hybrid GdMOF/AuNPs composites have been prepared by using poly(acrylic acid) as a bridge between the GdMOF nanopartides and AuNPs. The hybrid nanocomposites were then evaluated in MM and CT imaging. The results revealed high longitudinal relaxivity in MM and excellent CT imaging performance. Therefore, these GdMOF/AuNPs hybrid nanocomposites potentially provide a new platform for the development of multimodal imaging probes.
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