Journal
BONE
Volume 51, Issue 2, Pages 241-248Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2012.03.023
Keywords
Cartilage; Osteoarthritis; Aging; Senescence; Autophagy
Categories
Funding
- National Institute on Aging [AG007996, P30 AG021332]
- National Institute of Arthritis, Musculoskeletal and Skin Diseases [AR056026, AR49003]
- Sam and Rose Stein Endowment Fund
- Arthritis Foundation
- Dorothy Rhyne and Willard Duke Kimbrell Professorship
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This review is focused on aging-related changes in cells and extracellular matrix of the articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage, proteolysis, advanced glycation and calcification. The cellular changes include reduced cell density, cellular senescence with abnormal secretory profiles, and impaired cellular defense mechanisms and anabolic responses. The extracellular and cellular changes compound each other, leading to biomechanical dysfunction and tissue destruction. The consequences of aging-related changes for joint homeostasis and risk for osteoarthritis are discussed. This article is part of a Special Issue entitled Osteoarthritis. (C) 2012 Elsevier Inc. All rights reserved.
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