Journal
CURRENT HYPERTENSION REVIEWS
Volume 7, Issue 4, Pages 228-239Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340211799304761
Keywords
Adrenomedullin; angiogenesis; endothelial; lymphangiogenesis; mouse model; permeability; CLR; RAMPs
Categories
Funding
- NIH [HL091973, HD060860]
- Burroughs Wellcome Fund
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD060860] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL091973] Funding Source: NIH RePORTER
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Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.
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