Journal
CURRENT CARDIOLOGY REVIEWS
Volume 7, Issue 4, Pages 262-271Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340311799960618
Keywords
Cardiac hypertrophy; pro-hypertrophic; anti-hypertrophic; cardiac transcription factors; therapeutic targets; heart failure
Categories
Funding
- Department of Science and Technology, Government of India [SR/FT/LS-006/2009]
Ask authors/readers for more resources
Regulation of gene expression is central to cell growth, differentiation and diseases. Context specific and signal dependent regulation of gene expression is achieved to a large part by transcription factors. Cardiac transcription factors regulate heart development and are also involved in stress regulation of the adult heart, which may lead to cardiac hypertrophy. Hypertrophy of cardiac myocytes is an outcome of the imbalance between prohypertrophic factors and anti-hypertrophic factors. This is initially a compensatory mechanism but sustained hypertrophy may lead to heart failure. The growing knowledge of transcriptional control mechanisms is helpful in the development of novel therapies. This review summarizes the role of cardiac transcription factors in cardiac hypertrophy, emphasizing their potential as attractive therapeutic targets to prevent the onset of heart failure and sudden death as they can be converging targets for current therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available