Journal
BONE
Volume 48, Issue 3, Pages 557-561Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2010.10.004
Keywords
Primary hyperparathyroidism; Secondary hyperparathyroidism; Vitamin D deficiency; Histomorphometry; Cortical bone
Categories
Funding
- NIAMS NIH HHS [K24 AR052665, AR054041, AR056696] Funding Source: Medline
- NIDCR NIH HHS [DE019902] Funding Source: Medline
- NIDDK NIH HHS [R01 DK032333, R01 DK084986, K24 DK074457-05, K24 DK074457] Funding Source: Medline
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Introduction: Vitamin D deficiency is common in patients with primary hyperparathyroidism (PHPT). The presence of low levels of vitamin D may affect the skeletal consequences of PHPT. Methods: In this cross-sectional study, transiliac crest bone biopsies were performed after double tetracycline labeling in patients with mild PHPT and analyzed according to serum levels of 25 hydroxyvitamin D (25OHD). Results: We studied 30 patients with mild PHPT (age 53 +/- 11 years; 67% women; calcium 11.1 +/- 1.0 mg/dl; PTH 149 +/- 129 pg/ml). Serum 25OHD levels were low in the majority of subjects (mean 21 +/- 11 ng/ml) and inversely associated with PTH (r = -0.69; p < 0.01). 25OHD levels were directly associated with cortical width (Ct.Wi; r = 0.46, p < 0.03) and trabecular separation (Tb.Sp; r = 0.41; p < 0.04), but inversely associated with cancellous bone volume (BV/TV; r = -0.39, p < 0.04). Subjects with 25OHD levels < 20 ng/ml (n = 14) and >= 20 ng/ml (n = 16) were compared. Groups did not differ by age, sex, menopausal status, serum calcium, creatinine, or 1,25 (OH)(2)D. PTH was 1.8-fold higher in subjects with 25OHD < 20 (265 +/- 166 pg/ml vs. 95 +/- 50 pg/ml; p < 0.01). On histomorphometric analysis, those with low 25OHD had lower Ct.Wi (541 +/- 167 mu m vs. 712 +/- 200 mu m; p < 0.03). Conversely, measures of trabecular microarchitecture were better in those with lower 25OHD, with higher BV/TV (26.1 +/- 6.1% vs. 20.4 +/- 6.4%; p < 0.03), greater trabecular number (Tb.N: 2.0 +/- 0.4 mm(-1) vs. 1.8 +/- 0.4 mm(-1); p < 0.04) and lower Tb.Sp (371 +/- 90 mu m vs. 472 +/- 137 mu m; p < 0.04). There were no differences between the groups in bone remodeling indices. Conclusions: Low levels of 25OHD in patients with PHPT are associated with higher concentrations of PTH, greater catabolic effects in cortical bone and greater anabolic effects in trabecular bone. (C) 2010 Elsevier Inc. All rights reserved.
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